"Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it is the only thing that ever has."

Margaret Mead

Case report

Video Presentation of Myokymia in a Snakebite


Patients with snakebites have highly variable presentations, and delayed diagnosis may lead to unfavorable outcomes. Here, we describe the case of a snakebite in a 23-year-old male who presented with myokymias. On management with mechanical ventilation and anti-snake venom, the patient improved and was discharged. The presence of myokymias may be an early clue to diagnosis and the need for mechanical ventilation in a patient with a snakebite.


Snakebite is an important public health problem in many tropical and subtropical countries. Globally, at least 2.7 million envenomings and 80,000 to 138,000 deaths occur annually due to snakebite [1]. Clinical presentations can be variable depending upon the geographical location and the species of the snake. Systemic features include clotting defects, neurotoxicity, myotoxicity, cardiotoxicity, and nephrotoxicity [2]. Myokymia is a rare presentation of neurotoxic snakebite, characterized by spontaneous, fine, involuntary, undulating ripples of muscle fibers [3]. It has earlier been reported as a rare presentation of a bite from timber rattlesnake (Crotalus horridus) in the United States [4]. Here, we present a case of myokymia that resolved after two days of anti-snake venom therapy in India.

Case Presentation

A 23-year-old farmer was brought to casualty in a state of drowsiness with a brief history of limb weakness and difficulty in swallowing and speaking. Attendants stated that he witnessed a snake at his workplace but did not know if he was bitten. He had fairly stable vitals and a Glasgow Coma Scale score of 15. His pupils were mid-dilated and reacted normally to light. Bulbar weakness was present. The single breath count was nil as the patient was unable to speak. Diffuse involuntary undulating waves of muscle fibers likely myokymia were seen in upper and lower limbs bilaterally, as shown in Video 1.

The patient subsequently became unconscious within a few minutes and developed respiratory paralysis. He was intubated and started on mechanical ventilation. Snakebite was suspected according to history and clinical findings. He was administered stat intravenous dose of injection neostigmine 1.5 mg, followed by 0.5 mg every 30 minutes and injection atropine 0.6 mg intravenous every half-hourly. A total of 20 vials of polyvalent snake antivenom were administered over six hours as per the Government of India guidelines. Myokymias reduced significantly on the same day and disappeared completely over the next two days. The patient was weaned off the ventilator and subsequently discharged after full recovery.


Neurotoxic snakebites usually present as ptosis and external ophthalmoplegia, which can appear from minutes to hours after the bite. Subsequently, muscles of the face, neck, and deglutination become paralyzed. The involvement of intercostal muscles and diaphragm leads to respiratory failure [5]. Hemostatic abnormalities present as prolonged bleeding from a fang puncture wound or venipuncture site, epistaxis, hematemesis, hemoptysis, cutaneous ecchymosis, subconjunctival, retroperitoneal, or intracranial hemorrhage. Vipers and sea snakes may also cause intravascular hemolysis [2]. Myokymia, though not well defined in all snakebites, is a unique neurotoxic symptom previously reported in timber rattlesnake [4]. It is an involuntary vermicular movement of the muscles visualized over the skin as continuous ripples. It is difficult to distinguish from fasciculations which occur as individual muscle twitches. Myokymia is a chain of short-lived axonal bursts of a single motor unit firing at a rate of 5-150 Hz, with each burst occurring as a doublet or multiplet. Although fasciculations involve a single motor unit, they do not occur in cyclic bursts [3].

Interaction of snake venom with calcium or voltage-gated potassium channels in the nerve axons leading to modification in the axonal microenvironment may be the possible cause of myokymic discharge [3,4,6].

A case report from San Fernando described a 41-year-old male bitten by a pit viper who developed abdominal and limb pain along with diffuse myokymias in the thigh muscles. Electromyogram revealed neuronal hyperexcitability with mild myopathic features, while the electroencephalogram showed increased cortical irritability in the left parietal and temporal area. The authors described myokymia as a warning sign for mechanical ventilation, which was also required in our patient [7].

Another case report from Arizona described a 14-year-old boy bitten by a rattlesnake who presented with generalized myokymia over the face and limbs, with no significant coagulopathy, which resolved with 10 vials of antivenom. A 40-year-old woman bitten by a rattlesnake developed perioral paresthesias and myokymia, which resolved promptly with calcium chloride (2 g of 10%) indicating the role of snake venom and calcium channel interaction, as described above. Her clinical course was remarkable for local swelling, rhabdomyolysis, and mild hypofibrinogenemia for which she received 30 vials of polyvalent antivenom (Crotalidae). She was discharged later following marked clinical improvement [8].


At present, it is difficult to establish the exact cause of myokymia in snakebites. Further studies are required to identify other groups of snakebites that present with myokymia, how many patients with myokymia require mechanical ventilation, and whether they are responsible for rhabdomyolysis. However, early recognition is crucial as myokymia can be the first warning sign for mechanical ventilation and is easily reversed by snake antivenom.


  1. Williams DJ, Faiz MA, Abela-Ridder B, et al.: Strategy for a globally coordinated response to a priority neglected tropical disease: snakebite envenoming. PLoS Negl Trop Dis. 2019, 13:e0007059. 10.1371/journal.pntd.0007059
  2. Reid HA, Theakston RD: The management of snake bite. Bull World Health Organ. 1983, 61:885-95.
  3. Gutmann L, Gutmann L: Myokymia and neuromyotonia 2004. J Neurol. 2004, 251:138-42. 10.1007/s00415-004-0331-5
  4. Brick JF, Gutmann L, Brick J, Apelgren KN, Riggs JE: Timber rattlesnake venom-induced myokymia: evidence for peripheral nerve origin. Neurology. 1987, 37:1545-6. 10.1212/wnl.37.9.1545
  5. Warrell DA: Injuries, envenoming, poisoning, and allergic reactions caused by animals. Oxford Textbook of Medicine. Warrell DA, Cox TM, Firth JD (ed): Oxford University Press, Oxford, UK; 1996. 1126-39. 10.1093/med/9780199204854.003.0902
  6. Lewis RL, Gutmann L: Snake venoms and the neuromuscular junction. Semin Neurol. 2004, 24:175-9. 10.1055/s-2004-830904
  7. Ramcharan K, Abdool K, Persad N, Alexander A: Snake bite-induced myoclonus, myokymia and myospasm with leukoencephalopathy: a video presentation. BMJ Case Rep. 2016, 2016:10.1136/bcr-2016-214963. 10.1136/bcr-2016-214963
  8. LoVecchio F, Pizon AF, Wallace KL, Kunkel DB: Myokymia after snake envenomation in Arizona. Wilderness Environ Med. 2005, 16:116-7. 10.1580/1080-6032(2005)16[116:maseia]2.0.co;2

Case report

Video Presentation of Myokymia in a Snakebite

Author Information

Aman Garg

General Medicine, Government Medical College and Hospital, Chandigarh, Chandigarh, IND

Baldeep Kaur Corresponding Author

General Medicine, Government Medical College and Hospital, Chandigarh, Chandigarh, IND

Yuvraj S. Cheema

General Medicine, Government Medical College and Hospital, Chandigarh, Chandigarh, IND

Shivani Gupta

General Medicine, Government Medical College and Hospital, Chandigarh, Chandigarh, IND

Tagru Raju

General Medicine, Government Medical College and Hospital, Chandigarh, Chandigarh, IND

Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Case report

Video Presentation of Myokymia in a Snakebite

Figures etc.


Scholary Impact Quotient™ (SIQ™) is our unique post-publication peer review rating process. Learn more here.