"Never doubt that a small group of thoughtful, committed citizens can change the world. Indeed, it is the only thing that ever has."

Margaret Mead
Case report
peer-reviewed

When Nothing Else Works: Fresh Frozen Plasma in the Treatment of Progressive, Refractory Angiotensin-Converting Enzyme Inhibitor–Induced Angioedema



Abstract

Angioedema is a severe form of an allergic reaction characterized by the localized edematous swelling of the dermis and subcutaneous tissues. Angiotensin-converting enzyme inhibitor-induced angioedema (ACEI-IA) is an allergic reaction that can be severe in some cases requiring advanced management measures. Fresh frozen plasma has been used off-labeled in some case reports to improve and to prevent worsening of the angioedema in a few cases of ACEI-IA. We are reporting this case to increase the awareness of physicians and to widen their therapeutic options when encountering this clinically significant condition. 



Want to read more?

Create a free account to continue reading this article.

Already a member? Login.



Case report
peer-reviewed

When Nothing Else Works: Fresh Frozen Plasma in the Treatment of Progressive, Refractory Angiotensin-Converting Enzyme Inhibitor–Induced Angioedema


Author Information

Gerard Chaaya Corresponding Author

Internal Medicine, University of Central Florida College of Medicine

Faraz Afridi

Internal Medicine, University of Central Florida College of Medicine

Arfa Faiz

Internal Medicine, University of Central Florida College of Medicine

Ali Ashraf

Pulmonary/Critical Care, Osceola Regional Medical Center

Mahrukh Ali

Internal Medicine, University of Central Florida College of Medicine

Analia Castiglioni

Internal Medicine, University of Central Florida College of Medicine


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: The authors have declared that no conflicts of interest exist.


Case report
peer-reviewed

When Nothing Else Works: Fresh Frozen Plasma in the Treatment of Progressive, Refractory Angiotensin-Converting Enzyme Inhibitor–Induced Angioedema


Figures etc.

Share
Case report
peer-reviewed

When Nothing Else Works: Fresh Frozen Plasma in the Treatment of Progressive, Refractory Angiotensin-Converting Enzyme Inhibitor–Induced Angioedema

  • Author Information
    Gerard Chaaya Corresponding Author

    Internal Medicine, University of Central Florida College of Medicine

    Faraz Afridi

    Internal Medicine, University of Central Florida College of Medicine

    Arfa Faiz

    Internal Medicine, University of Central Florida College of Medicine

    Ali Ashraf

    Pulmonary/Critical Care, Osceola Regional Medical Center

    Mahrukh Ali

    Internal Medicine, University of Central Florida College of Medicine

    Analia Castiglioni

    Internal Medicine, University of Central Florida College of Medicine


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: The authors have declared that no conflicts of interest exist.

    Acknowledgements


    Article Information

    Published: January 11, 2017

    DOI

    10.7759/cureus.972

    Cite this article as:

    Chaaya G, Afridi F, Faiz A, et al. (January 11, 2017) When Nothing Else Works: Fresh Frozen Plasma in the Treatment of Progressive, Refractory Angiotensin-Converting Enzyme Inhibitor–Induced Angioedema. Cureus 9(1): e972. doi:10.7759/cureus.972

    Publication history

    Received by Cureus: December 08, 2016
    Peer review began: December 27, 2016
    Peer review concluded: January 04, 2017
    Published: January 11, 2017

    Copyright

    © Copyright 2017
    Chaaya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Angioedema is a severe form of an allergic reaction characterized by the localized edematous swelling of the dermis and subcutaneous tissues. Angiotensin-converting enzyme inhibitor-induced angioedema (ACEI-IA) is an allergic reaction that can be severe in some cases requiring advanced management measures. Fresh frozen plasma has been used off-labeled in some case reports to improve and to prevent worsening of the angioedema in a few cases of ACEI-IA. We are reporting this case to increase the awareness of physicians and to widen their therapeutic options when encountering this clinically significant condition. 



Want to read more?

Create a free account to continue reading this article.

Already a member? Login.



Gerard Chaaya, Resident Physician

Internal Medicine, University of Central Florida College of Medicine

For correspondence:
gerard.chaaya@ucf.edu

Faraz Afridi, M.D.

Internal Medicine, University of Central Florida College of Medicine

Arfa Faiz

Internal Medicine, University of Central Florida College of Medicine

Ali Ashraf

Pulmonary/Critical Care, Osceola Regional Medical Center

Mahrukh Ali

Internal Medicine, University of Central Florida College of Medicine

Analia Castiglioni, M.D.

Internal Medicine, University of Central Florida College of Medicine

Gerard Chaaya, Resident Physician

Internal Medicine, University of Central Florida College of Medicine

For correspondence:
gerard.chaaya@ucf.edu

Faraz Afridi, M.D.

Internal Medicine, University of Central Florida College of Medicine

Arfa Faiz

Internal Medicine, University of Central Florida College of Medicine

Ali Ashraf

Pulmonary/Critical Care, Osceola Regional Medical Center

Mahrukh Ali

Internal Medicine, University of Central Florida College of Medicine

Analia Castiglioni, M.D.

Internal Medicine, University of Central Florida College of Medicine