Point of care ultrasound (PoCUS) has become an established tool in the initial management of patients with undifferentiated hypotension. Current established protocols (RUSH and ACES) were developed by expert user opinion, rather than objective, prospective data. PoCUS also provides invaluable information during resuscitation efforts in cardiac arrest by determining presence/absence of cardiac activity and identifying reversible causes such as pericardial tamponade. There is no agreed guideline on how to safely and effectively incorporate PoCUS into the advanced cardiac life support (ACLS) algorithm. We wished to report disease incidence as a basis to develop a hierarchical approach to PoCUS in hypotension and during cardiac arrest.
We summarized the recorded incidence of PoCUS findings from the initial cohort during the interim analysis of two prospective studies. We propose that this will form the basis for developing a modified Delphi approach incorporating this data to obtain the input of a panel of international experts associated with five professional organizations led by the International Federation of Emergency Medicine (IFEM). The modified Delphi tool will be developed to reach an international consensus on how to integrate PoCUS for hypotensive emergency department patients as well as into cardiac arrest algorithms.
Rates of abnormal PoCUS findings from 151 patients with undifferentiated hypotension included left ventricular dynamic changes (43%), IVC abnormalities (27%), pericardial effusion (16%), and pleural fluid (8%). Abdominal pathology was rare (fluid 5%, AAA 2%). During cardiac arrest there were no pericardial effusions, however abnormalities of ventricular contraction (45%) and valvular motion (39%) were common among the 43 patients included.
A prospectively collected disease incidence-based hierarchy of scanning can be developed based on the reported findings. This will inform an international consensus process towards the development of proposed SHoC protocols for hypotension and cardiac arrest, comprised of the stepwise clinical-indication based approach of Core, Supplementary, and Additional PoCUS views. We hope that such a protocol would be structured in a way that enables the clinician to only perform views that are clinically indicated, which limits exposure to the frequent incidental positive findings that accompany the current “one size fits all” standard protocols.
The use of point of care ultrasound (PoCUS) as an adjunct to the practice of emergency medicine is now well established internationally. Initially, evidence to support the use of PoCUS came from the management of blunt trauma patients . The scope of practice has expanded as emergency physicians have identified further clinical problems where PoCUS is able to aid diagnosis and guide procedures. Assessment of patients in cardiac arrest and with undifferentiated hypotension have been core applications of PoCUS, with various protocols in widespread use in emergency medicine [2-3]. Such protocols are based upon a logical approach to identifying the likely etiology and guiding therapy, but these are frequently based solely on expert opinion and not on the actual incidence of disease. They have become essential components of the initial investigation for patients presenting with undifferentiated hypotension, as they enable clinicians to quickly and accurately determine the source of shock . In this paper we present the incidence of positive findings that we hope will inform the development of a Sonography in Hypotension and Cardiac Arrest (SHoC) Protocol so that clinicians may safely incorporate PoCUS into the resuscitation of the hypotensive or arrested patient. To initiate development of this protocol, we report the incidence of PoCUS findings from the interim analyses of two ongoing prospective studies involving emergency department patients in cardiac arrest or with undifferentiated hypotension. These observed incidences will provide insight into the value of each specific ultrasound view. We plan that the protocol will be further developed by a structured review process involving a panel of 24 international experts associated with five international professional organizations, led by the International Federation for Emergency Medicine (IFEM) ultrasound curriculum group.
Materials & Methods
We reviewed and report all findings from the interim analyses of two multicenter prospective studies. These studies examined ultrasound use in undifferentiated hypotension and in cardiac arrest. In each study, comprehensive point of care ultrasound protocols were completed. The interim analyses were scheduled for a recruitment point of 150 patients in first Sonography in Hypotension and Cardiac Arrest in the Emergency Department (SHoC-ED1) study (Research Ethics Board Approval Number HHN RS 2011-1590; unpublished data) and on completion of local data collection in the Sonography in cardiac arrest: Real-time Assessment and Evaluation with Sonography – Outcomes Network (REASON) study (Research Ethics Board Approval Number HHN RS#2011-1566; unpublished data).
Rates of abnormal PoCUS findings in 82 patients from the first included 151 SHoC-ED1 patients with undifferentiated hypotension are shown in Table 1 and consisted of cardiac, IVC and lung findings, including left ventricular dynamic changes (43%), IVC abnormalities (27%), pericardial effusion (16%), and pleural fluid (8%). Abdominal pathology was rare (fluid 5%, AAA 2%).
Data was analyzed for 43 patients who had sonography performed during cardiac arrest during the REASON study. Abnormal findings are summarized in Table 2. There were no pericardial effusions, however abnormalities of ventricular contraction (45%) and valvular motion (39%) were common.
The rate of findings from these studies indicates that most positive finds relate to cardiac, lung, and IVC scanning. This data shows that there may be a low yield for certain previously suggested components of protocols, including aorta and abdominal scanning. We hope to provide these results to a panel of experts to be used, along with their combined clinical expertise, to identify what role a given view should play in the proposed SHoC protocol. This panel will be asked to consider the evidence they were provided and to vote in a way that would yield an efficient protocol consistent with current PoCUS practice and resuscitation science. When deriving this protocol, the SHoC team identified an international trend in the approach to teaching PoCUS. This trend recognizes four features that any protocol must identify to be able to adequately assess a person’s cardiovascular status. By ensuring that the SHoC protocol has the same foundations as the current approach to teaching ultrasound internationally, we hope to maximize clinician familiarity with our protocol. The features that constitute the “4F” approach are described in Table 3.
The SHoC derivation team will examine the literature and will consult our expert panel to identify views that may be valuable in identifying aetiology of undifferentiated hypotension and which views are a priority in cardiac arrest patients. To reach an unbiased consensus, the Delphi Method will be implemented .
The Delphi method
The Delphi method is a consensus-building tool that has been used in many fields (medical and otherwise) to enable a group to arrive at a “round table” conclusion. This is done using a central non-voting coordinator who identifies a set of “issues” the panel must address. For each issue, a list of discrete possible options is provided to the expert panel. The experts then answer the “issues” with one of the provided responses, and also provide a rationale for their decision. The central coordinator then reviews the panel’s responses. If a consensus about a certain issue is reached, that issue does not need to be included in future iterations of the Delphi method. If, however, consensus is not reached for an issue, the central coordinator examines the rationales provided by the experts, and collates these into “opinion summaries”. Options that are unpopular and therefore unlikely to develop into consensus are eliminated from future rounds. The remaining options, as well as the opinion summaries and the frequencies with which those options were selected are then again presented to the panel. The process then repeats in the next iteration. This continues until consensus is built, and reasonable options are found for all issues. We plan to develop a hierarchical approach to PoCUS in hypotension and cardiac arrest using the categories outlined in Table 4.
We present an approach to develop an international consensus for the use of sonography in hypotension and cardiac arrest (SHoC) based on prospectively collected disease incidence. The proposed SHoC protocols for hypotension and cardiac arrest would be stepwise clinical-indication based approaches, incorporating core, supplementary, and additional PoCUS views focusing on scanning for fluid, form, function and filling.
- Scalea T, Rodriguez A, Chiu W, et al.: Focused assessment with sonography for trauma (FAST): results from an international consensus conference. J Trauma. 1999, 46:466-472. 10.1097/00005373-199903000-00022
- Perera P, Mailhot T, Riley D, Mandavia D: The RUSH exam: rapid ultrasound in shock in the evaluation of the critically ill. Emerg Med Clin North Am. 2010, 28:29-56. 10.1016/j.emc.2009.09.010
- Atkinson P, McAuley D, Kendall R, Abeyakoon O, Reid C, Connolly J, Lewis D: Abdominal and cardiac evaluation with sonography in shock (ACES): an approach by emergency physicians for the use of ultrasound in the undifferentiated hypotensive patient. Emerg Med J. 2009, 26:87-91. 10.1136/emj.2007.056242
- Jones A, Tayal V, Sullivan D, Kline J: Randomized, controlled trial of immediate versus delayed goal-directed ultrasound to identify the cause of nontraumatic hypotension in emergency department patients. Crit Care Med. 2004, 32:1703-1708. 10.1097/01.CCM.0000133017.34137.82
- Okoli C, Pavlovski S: Delphi method as a research tool: an example, design considerations and applications. Information & Management. 2004, 42:15-29. 10.1016/j.im.2003.11.002
Sonography in Hypotension and Cardiac Arrest (SHoC): Rates of Abnormal Findings in Undifferentiated Hypotension and During Cardiac Arrest as a Basis for Consensus on a Hierarchical Point of Care Ultrasound Protocol
Ethics Statement and Conflict of Interest Disclosures
Human subjects: Consent was obtained by all participants in this study. Horizon Health Network issued approval HHN RS 2011-1590. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: Horizon Health Network Health Promotion Research Fund local grant for $10,000 CAD. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
We acknowledge Dr Romolo Gaspari and the REASON study team for providing the cardiac arrest ultrasound protocol. We acknowledge Ms. Nicole Beckett for her comments on the project, and the medical staff who completed the data collection forms.
Cite this article as:
Milne J, Atkinson P, Lewis D, et al. (April 08, 2016) Sonography in Hypotension and Cardiac Arrest (SHoC): Rates of Abnormal Findings in Undifferentiated Hypotension and During Cardiac Arrest as a Basis for Consensus on a Hierarchical Point of Care Ultrasound Protocol. Cureus 8(4): e564. doi:10.7759/cureus.564
Received by Cureus: March 24, 2016
Peer review began: March 26, 2016
Peer review concluded: April 06, 2016
Published: April 08, 2016
© Copyright 2016
Milne et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.