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Case report
peer-reviewed

Bouveret’s Syndrome



Abstract

Bouveret syndrome is a very rare form of gastric outlet obstruction following the passage of a gallstone from the gallbladder to the duodenum or pylorus through a bilioenteric fistula. We present a unique case of a 78-year-old male complaining of right upper quadrant abdominal pain and who was found to have a gallstone in the proximal duodenum along with pneumobilia and cholecysto-duodenal fistula suggestive of Bouveret’s syndrome.

Introduction

Bouveret’s syndrome is a rare variant of gallstone ileus, which is caused by the impaction of a gallstone in the duodenum. The gallstone erodes through the wall of gallbladder and duodenum creating a bilioenteric fistula due to persistent inflammation in the surrounding area and pressure necrosis. We report a case of Bouveret’s syndrome in an elderly male who presented with a gastric outlet obstruction. 

Case Presentation

A 78-year-old Caucasian man presented to the emergency room with a sudden onset of severe, intermittent, cramping right upper quadrant abdominal pain with non-bloody, non-bilious vomiting for one day. His personal history included atrial fibrillation and atrioventricular block with an implanted pacemaker. On examination, the abdomen was soft with mild epigastric tenderness, decreased bowel sounds and distension. Labs revealed leukocytosis of 12.46 TH/MM3, alkaline phosphatase of 321 IU/L, aspartate aminotransferase of 52 IU/L, alanine aminotransferase of 47 IU/L, total bilirubin of 1.8 mg/dl, and serum lipase of 161 U/L. An abdominopelvic computed tomography (CT) revealed a 6.6 x 4.4 cm gallstone in the proximal duodenum with surrounding inflammation, cholecysto-duodenal fistula, and pneumobilia (Figure 1).

Upper endoscopy was performed revealing complete obstruction of the duodenum due to the impacted stone (Figure 2).

Several endoscopic foreign body and stone retrieval devices, as well as lithotripsy, were attempted to remove or fragment the stone. However, the stone was impacted and exceedingly larger than the available endoscopic retrieval devices. Another attempt was made to inflate the controlled radial expansion (CRE) dilation balloon beyond the impacted stone and drag the stone into the stomach for fragmentation, but it was unsuccessful (Figure 3).

Endoscopic guided electrohydraulic lithotripsy (EHL) was performed, which led to partial fragmentation of the stone. We were able to create a tunnel through the stone but was unable to break the outer shell despite using multiple probes at high power. Laparoscopy was then attempted although he eventually required laparotomy due to adhesions. The stone was successfully extracted through duodenotomy as seen in Figure 4, followed by closure of the cholecysto-duodenal fistula, cholecystectomy, and placement of a temporary feeding gastrojejunostomy tube. The postoperative course remained uneventful, and the patient was discharged after four days.

Discussion

Gallstone ileus causes intestinal obstruction in 1%-4 % of the cases, of which Bouveret’s syndrome comprises of only 1%-3%. This rare syndrome was first described in 1896 by Leon Bouveret, a French physician, which since then bears his name [1]. It occurs more commonly in elderly women with a median age of 74 years [2]. This is a clinically distinct entity owing to proximal gastrointestinal obstruction, usually caused by large (usually >2.5cm) gallstone [3].

The clinical presentation is nonspecific, varying from gastric outlet obstruction as seen in our case, to acute pancreatitis, upper gastrointestinal bleeding, duodenal perforation, Boerhaave's syndrome and gastric bezoars formation [4-10]. A classic Rigler’s triad of dilated stomach, pneumobilia, and ectopic stone appearing as a filling defect in the duodenum seen on a CT scan is virtually pathognomonic of the Bouveret’s syndrome [11]. This triad is diagnostic in only 21% of the cases with a conventional radiograph [12]. Nevertheless, 15%-25% of the times gallstones are difficult to identify on a CT as they are isodense to adjacent liquid [11]. Thus, high clinical suspicion with appropriate diagnostic imaging helps make the diagnosis easier.

The primary therapeutic goal is gallstone retrieval. Majority of the patients with Bouveret’s being elderly, with a high incidence of concomitant disorders, do carry a high risk of morbidity and mortality post-surgery. Thus esophagogastroduodenoscopy (EGD) plays a significant role both as a diagnostic and therapeutic modality and must be considered as a first line treatment despite its low success rate [13]. There have been case reports of successful retrieval of gallstones of up to 3 cm using endoscopy [14-15]. The different endoscopic methods described are mechanical lithotripsy, laser lithotripsy, extracorporeal shockwave lithotripsy, and intracorporeal electrohydraulic lithotripsy as used in our report [16-17]. The choice of procedure mainly depends upon the availability at the individual center and the endoscopist. A major drawback of all these techniques the risk of dislodgment of the stone fragment distally, causing small bowel obstruction [16].

Despite these advances, surgery is needed in most of the patients with this disease. Surgery can be done laparoscopically or through laparotomy. As in our case, laparoscopic surgery was initially attempted, but it was not successful due to adhesions. Surgical options include enterolithotomy or gastrostomy with or without gallbladder removal and repair of the fistula [13,18]. There is a paucity of data supporting simple surgical stone extraction as oppose to simultaneous cholecystectomy and fistula closure.

Conclusions

In conclusion, Bouveret’s syndrome is a rare entity and remains a diagnostic and therapeutic challenge. An initial endoscopic trial must always be performed. In cases requiring surgical intervention, a tailored approach must be considered based on individual age and co-morbidities in relation to the morbidity and mortality rates of each approach.


References

  1. Bouveret L: Stenose du pylore adhérent à la vesicule [Article in French]. Rev Med (Paris). 1896, 16:1-16.
  2. Cappell MS, Davis M: Characterization of Bouveret's syndrome: a comprehensive review of 128 cases. Am J Gastroenterol. 2006, 101:2139-2146. 10.1111/j.1572-0241.2006.00645.x
  3. Koulaouzidis A, Moschos J: Bouveret's syndrome. Narrative review. Ann Hepatol. 2007, 6:89-91.
  4. Rehman A, Hasan Z, Saeed A, et al.: Bouveret's syndrome. J Coll Physicians Surg Pak. 2008, 18:435-437.
  5. Zafar A, Ingham G, Jameel JK: "Bouveret's syndrome" presenting with acute pancreatitis a very rare and challenging variant of gallstone ileus. Int J Surg Case Rep. 2013, 4:528-530. 10.1016/j.ijscr.2013.01.017
  6. Mengual-Ballester M, Guillen-Paredes MP, Cases-Baldo MJ, Garcia-Garcia ML, Aguayo-Albasini JL: Gastrointestinal bleeding and bowel obstruction as a presentation of Bouveret syndrome. Cir Cir. 2011, 79:557-559.
  7. Wonaga A, Fritz V, D'Alessandro M, Waldbaum C: Bouveret syndrome: unusual cause of upper gastrointestinal bleeding [Article in Spanish]. Acta Gastroenterol Latinoam. 2010, 40:159-161.
  8. Harthun NL, Long SM, Wilson W, Choudhury A: An unusual case of Bouveret's syndrome. J Laparoendosc Adv Surg Tech. 2002, 12:69-72. 10.1089/109264202753486975
  9. Modi BP, Owens C, Ashley SW, Colson YL: Bouveret meets Boerhaave. Ann Thorac Surg. 2006, 81:1493-1495. 10.1016/j.athoracsur.2005.04.049
  10. Tadros GM, Draganescu JM, Clarke LE, Albornoz MA: Intragastric gallstone-induced bezoar: an unusual cause of acute gastric outlet obstruction. South Med J. 2002, 95:261-264.
  11. Gijon-de-la-Santa L, Camarero-Miguel A, Perez-Retortillo JA, Ramia-Angel JM: Bouveret's syndrome: evaluation with multidetector CT. Rev Esp Enferm Dig. 2014, 106:283-284.
  12. Gallego Otaegui L, Sainz Lete A, Gutierrez Rios R, et al.: A rare presentation of gallstones: Bouveret s syndrome, a case report. Rev Esp Enferm Dig. 2016, 108:434-436.
  13. Nickel F, Muller-Eschner MM, Chu J, von Tengg-Kobligk H, Muller-Stich BP: Bouveret's syndrome: presentation of two cases with review of the literature and development of a surgical treatment strategy. BMC Surg. 2013, 13:33. 10.1186/1471-2482-13-33
  14. Moriai T, Hasegawa T, Fuzita M, Kimura A, Tani T, Makino I: Successful removal of massive intragastric gallstones by endoscopic electrohydraulic lithotripsy and mechanical lithotripsy. Am J Gastroenterol. 1991, 86:627-629.
  15. Huebner ES, DuBois S, Lee SD, Saunders MD: Successful endoscopic treatment of Bouveret's syndrome with intracorporeal electrohydraulic lithotripsy. Gastrointest Endosc. 2007, 66:183-184. 10.1016/j.gie.2007.01.024
  16. Qasaimeh GR, Bakkar S, Jadallah K: Bouveret's syndrome: an overlooked diagnosis. A case report and review of literature. Int Surg. 2014, 99:819-823.
  17. Maiss J, Hochberger J, Hahn EG, Lederer R, Schneider HT, Muehldorfer S: Successful laserlithotripsy in Bouveret's syndrome using a new frequency doubled doublepulse Nd:YAG laser (FREDDY). Scand J Gastroenterol. 2004, 39:791-794. 10.1080/00365520410005937
  18. Mavroeidis VK, Matthioudakis DI, Economou NK, Karanikas ID: Bouveret syndrome-the rarest variant of gallstone ileus: a case report and literature review. Case Rep Surg. 2013, 2013:839370. 10.1155/2013/839370
Case report
peer-reviewed

Bouveret’s Syndrome


Author Information

Jobin Philipose Corresponding Author

Internal Medicine, Staten Island University Hospital - Northwell Health, Staten Island, USA

Hafiz M. Khan

Gastroenterology and Hepatology, Zucker School of Medicine at Hofstra Northwell, Staten Island University Hospital - Northwell Health, Staten Island, USA

Moiz Ahmed

Gastroenterology, Icahn School of Medicine at Elmhurst Hospital Center, Elmhurst, USA

Internal Medicine, Staten Island University Hospital - Northwell Health, Staten Island, USA

Pretty S. Idiculla

Internal Medicine, Staten Island University Hospital - Northwell Health, Staten Island, USA

Sherif Andrawes

Gastroenterology, Staten Island University Hospital - Northwell Health, Staten Island, USA


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


Case report
peer-reviewed

Bouveret’s Syndrome


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