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Review article
peer-reviewed

Celiac Disease and Concomitant Conditions: A Case-based Review



Abstract

Celiac disease is a chronic autoimmune disease with genetic predisposition, triggered by the ingestion of gluten. It has a wide range of clinical manifestations ranging from asymptomatic forms to classic presentation of malabsorption with diarrhea and abdominal cramps. Celiac disease can also present with several other concomitant disorders (at the time of diagnosis or during the course of celiac disease) such as: type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, thyroid disorders, nutritional deficiencies, and gram-negative sepsis. We present a 57-year-old female with past medical history of rheumatoid arthritis, who presented to the emergency department with a complaint of chronic diarrhea, complicated by gram-negative sepsis. The family history of the patient was significant for celiac disease, type 1 diabetes, and rheumatoid arthritis. The patient was closely monitored and treated appropriately. In this case-based review, we explore different associated conditions of celiac disease in the literature, as well as the patient's risk of developing malignancy.



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Review article
peer-reviewed

Celiac Disease and Concomitant Conditions: A Case-based Review


Author Information

Muhammad Uzair Lodhi

Medical Student, Department of Medicine, Raleigh General Hospital, Beckley, Wv

Tracy Stammann

Medical Student, Lincoln Memorial University-Debusk College of Osteopathic Medicine

Aaron R. Kuzel

Department of Emergency Medicine, Lincoln Memorial University-Debusk College of Osteopathic Medicine

Intekhab Askari Syed Corresponding Author

Medical Student, Department of Medicine, Raleigh General Hospital, Beckley, Wv

Medical Student, Department of Medicine, Beckley Appalachian Regional Healthcare

Rizwan Ishtiaq

Gastroenterology, Beth Israel Deaconess Medical Center, Boston

Mustafa Rahim

Assistant Clinical Professor of Internal Medicine, West Virginia University School of Medicine

Adjunct Faculty, Lincoln Memorial University, School of Medicine


Ethics Statement and Conflict of Interest Disclosures

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Acknowledgements

We would like to thank Dr. Fausto D. Imbing and Dr. Bijan Amirghassemi for their help with the pathology slides.


Review article
peer-reviewed

Celiac Disease and Concomitant Conditions: A Case-based Review


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Review article
peer-reviewed

Celiac Disease and Concomitant Conditions: A Case-based Review

  • Author Information
    Muhammad Uzair Lodhi

    Medical Student, Department of Medicine, Raleigh General Hospital, Beckley, Wv

    Tracy Stammann

    Medical Student, Lincoln Memorial University-Debusk College of Osteopathic Medicine

    Aaron R. Kuzel

    Department of Emergency Medicine, Lincoln Memorial University-Debusk College of Osteopathic Medicine

    Intekhab Askari Syed Corresponding Author

    Medical Student, Department of Medicine, Raleigh General Hospital, Beckley, Wv

    Medical Student, Department of Medicine, Beckley Appalachian Regional Healthcare

    Rizwan Ishtiaq

    Gastroenterology, Beth Israel Deaconess Medical Center, Boston

    Mustafa Rahim

    Assistant Clinical Professor of Internal Medicine, West Virginia University School of Medicine

    Adjunct Faculty, Lincoln Memorial University, School of Medicine


    Ethics Statement and Conflict of Interest Disclosures

    Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

    Acknowledgements

    We would like to thank Dr. Fausto D. Imbing and Dr. Bijan Amirghassemi for their help with the pathology slides.


    Article Information

    Published: February 02, 2018

    DOI

    10.7759/cureus.2143

    Cite this article as:

    Lodhi M, Stammann T, Kuzel A R, et al. (February 02, 2018) Celiac Disease and Concomitant Conditions: A Case-based Review. Cureus 10(2): e2143. doi:10.7759/cureus.2143

    Publication history

    Received by Cureus: January 26, 2018
    Peer review began: January 30, 2018
    Peer review concluded: January 30, 2018
    Published: February 02, 2018

    Copyright

    © Copyright 2018
    Lodhi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Celiac disease is a chronic autoimmune disease with genetic predisposition, triggered by the ingestion of gluten. It has a wide range of clinical manifestations ranging from asymptomatic forms to classic presentation of malabsorption with diarrhea and abdominal cramps. Celiac disease can also present with several other concomitant disorders (at the time of diagnosis or during the course of celiac disease) such as: type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, thyroid disorders, nutritional deficiencies, and gram-negative sepsis. We present a 57-year-old female with past medical history of rheumatoid arthritis, who presented to the emergency department with a complaint of chronic diarrhea, complicated by gram-negative sepsis. The family history of the patient was significant for celiac disease, type 1 diabetes, and rheumatoid arthritis. The patient was closely monitored and treated appropriately. In this case-based review, we explore different associated conditions of celiac disease in the literature, as well as the patient's risk of developing malignancy.



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