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Editorial
peer-reviewed

Pain Perception and the Opioid Receptor Delta 1



Abstract

Genetic factors play an integral role in the perception of pain, and studies have only recently begun to explore the degree to which these factors affect clinical decisions. The process of prescribing opioids is greatly influenced by an individual's pain perception, which can vary based on several factors including genetic variation. Opioid receptor delta 1 (OPRD1) plays a significant role in the perception of both pain and its relief via opioids, and it shows significant variability between individuals. Herein, we discuss the nature of the OPRD1 receptor and the value of further research into its effects, particularly in the realm of pain management.



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Editorial
peer-reviewed

Pain Perception and the Opioid Receptor Delta 1


Author Information

Adam T. Hilgemeier

School of Pharmacy, Texas Tech University Health Sciences Center

David M. Serna

School of Pharmacy, Texas Tech University Health Sciences Center

Tarak P. Patel

School of Pharmacy, Texas Tech University Health Sciences Center

Kerry Anne Rambaran

Department of Clinical Sciences, Keck Graduate Institute

Zubair M. Amin

Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific

Jie An

Gulfstream Genomics, Gulfstream Diagnostics

Saeed K. Alzghari Corresponding Author

Gulfstream Genomics, Gulfstream Diagnostics


Ethics Statement and Conflict of Interest Disclosures

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: Jie An and Saeed K. Alzghari declare(s) employment from Gulfstream Diagnostics. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


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Editorial
peer-reviewed

Pain Perception and the Opioid Receptor Delta 1

  • Author Information
    Adam T. Hilgemeier

    School of Pharmacy, Texas Tech University Health Sciences Center

    David M. Serna

    School of Pharmacy, Texas Tech University Health Sciences Center

    Tarak P. Patel

    School of Pharmacy, Texas Tech University Health Sciences Center

    Kerry Anne Rambaran

    Department of Clinical Sciences, Keck Graduate Institute

    Zubair M. Amin

    Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific

    Jie An

    Gulfstream Genomics, Gulfstream Diagnostics

    Saeed K. Alzghari Corresponding Author

    Gulfstream Genomics, Gulfstream Diagnostics


    Ethics Statement and Conflict of Interest Disclosures

    Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: Jie An and Saeed K. Alzghari declare(s) employment from Gulfstream Diagnostics. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

    Acknowledgements


    Article Information

    Published: February 04, 2018

    DOI

    10.7759/cureus.2149

    Cite this article as:

    Hilgemeier A T, Serna D M, Patel T P, et al. (February 04, 2018) Pain Perception and the Opioid Receptor Delta 1. Cureus 10(2): e2149. doi:10.7759/cureus.2149

    Publication history

    Received by Cureus: January 15, 2018
    Peer review began: January 16, 2018
    Peer review concluded: January 31, 2018
    Published: February 04, 2018

    Copyright

    © Copyright 2018
    Hilgemeier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Genetic factors play an integral role in the perception of pain, and studies have only recently begun to explore the degree to which these factors affect clinical decisions. The process of prescribing opioids is greatly influenced by an individual's pain perception, which can vary based on several factors including genetic variation. Opioid receptor delta 1 (OPRD1) plays a significant role in the perception of both pain and its relief via opioids, and it shows significant variability between individuals. Herein, we discuss the nature of the OPRD1 receptor and the value of further research into its effects, particularly in the realm of pain management.



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