Gamma Knife Radiosurgery in Pediatric Patients



Abstract

Objectives:

Although radiation modalities are common among pediatric patients, GKRS is a rare modality. The objective is to show the patient demographic in a reference GKRS service over 20 years and different applicability.

Methods:

Retrospective review of patients under 18 years treated with GKRS from 1999 to 2020. It was considered the primary pathology, age, dose, lesion volume, use of frame versus mask, single session versus hypofractionation. Gamma Knife Model C, Perfection and Icon were used.

Results:

Fifty-five patients were submitted to 80 treatments, age varied from 3 to 18, being the majority between 15 and 18 yo. Tumors represented 55% and AVMs 45%. Seventy-three procedures used Leksell frame and 7 used thermoplastic mask, being 6 for single session and 1 for 5-session hypofractionation. Median dose was 20Gy (8-28) and lesion volume was 1.066cc (0.081-34.791). No secondary tumor was observed until now.

Conclusion(s):

GKRS is a visible modality for radiation treatment for pediatric patients allowing several techniques for a great variety of pathologies. For younger patients, sedation is needed for tolerance and safety. GKRS is an applicable treatment modality for pediatric patients and individual considerations with a multi-disciplinary team should be made.

Related content

abstract
non-peer-reviewed

Gamma Knife Radiosurgery in Pediatric Patients


Author Information

Victor Goulenko Corresponding Author

Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, USA

Dheerendra Prasad

Neurosurgery and Radiology, Roswell Park Cancer Institute, Buffalo, USA

Matthew Recker

Neurosurgery, Roswell Park Comprehensive Cancer Center, Buffalo, USA


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