Cureus | Potential Advantages to Radiobiological Optimization as Compared with Conventional Physical Optimization for Stereotactic Treatment Planning

Potential Advantages to Radiobiological Optimization as Compared with Conventional Physical Optimization for Stereotactic Treatment Planning



Abstract

Objective: To investigate the different planning optimization methods (Physical and radiobiological) in stereotactic treatments for a variety of anatomical sites.

Methods: Thirty patients were selected retrospectively following treatment with stereotactic VMAT treatments based on standard physical planning objective optimization: brain n=10; thorax n=10; and spine n=10. For each patient, an additional Stereotactic VMAT plan was generated using a radiobiological planning optimization method, incorporating gEUD concepts in Varian Eclipse (version 15.1).  Radiobiological metrics were estimated using BioSuite software (NTCP models & EUD).  Dosimetric parameters of CI, Gradient Index, HI, MU and DVH constraints, were compared, across plans, with statistical significance determined by Kruskal-Wallis test (2-tailed p < 0.05).

Results: Optimization in stereotactic plans were better for radiobiological optimization compared with physical objective optimization, for the dosimetric parameters mean p-value being 0.0168, SD=0.0119 and for the radiobiological parameter mean of p being 0.0126, SD=0.0108.

Conclusion: Radiobiological optimization in stereotactic treatment plans showed a statistical advantage.  This was more apparent in highly heterogeneous dose distributions around the target, especially regarding the sparing of surrounding critical organs.

Related content

abstract
non-peer-reviewed

Potential Advantages to Radiobiological Optimization as Compared with Conventional Physical Optimization for Stereotactic Treatment Planning


Author Information

Abdul Aziz Saith Corresponding Author

Medical Physics, Group of north american oncology, Moradabad, IND

Thanh Nguyen

Medical Physics, Advanced Medical Physics Inc., Houston, USA

Daniel Rucka

Medical Physics, Advanced Medical Physics Inc., Houston, USA

Rebecca Mathew

Medical Physics, Advanced Medical Physics Inc., Houston, USA

Nikhil Rastogi

Medical Physics, IFTM University, Moradabad, IND

Jason Berilgen

Radiation Oncology, Millennium Physicians, Spring, USA

Sunil Mani

Medical Physics, Advanced Medical Physics Inc., Houston, USA


PDF Share