Background: Few medical students are exposed to evidence-based, multidisciplinary oncology care, and few studies in oncology education reflect consolidated preclinical curricula. Fourth-year medical students were introduced to a four-week curriculum, “Frontiers in Neoplasia”, which included didactic lectures, interactive site visits, and team-based simulations of tumor boards and clinical trial design.  

Methods: To analyze the course’s impact, students’ pre- and post-course responses to Likert-scale clinical evidence questions were analyzed using Wilcoxon rank-sum tests. Students’ general course feedback was analyzed using thematic coding analysis.  

Results: Of the 107 enrolled fourth-year medical students between 2021-2024, 94 completed the pre-survey and 96 completed the post-survey. Quantitative analysis showed a significant increase in students’ comfort in evidence-based medicine in oncology (p < .001). Students enjoyed the multidisciplinary curriculum, diverse hybrid-format learning modalities, and applicability of coursework to their careers. 

Conclusion: Our novel oncology curriculum significantly increased students’ confidence in navigating emerging approaches to cancer care.