The increasing demand to identify new non-pharmacological strategies for pain management in pediatric patients has spurred new research in the academic field: recent studies show that immersive technologies, particularly Virtual Reality (VR), can be promising tools for the reduction of pain in pediatric patients. This systematic review investigates the efficacy of the most recent VR systems in reducing pediatric pain. This systematic review will seek to answer two questions: (1) Is VR an effective tool for reducing pediatric pain?; (2) Is VR a more effective tool for reducing pediatric pain compared to current standard treatments?. The following review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Studies were identified through the use of the PubMed, EBSCOhost, and Cochrane Library databases. A total of 9 articles met the eligibility criteria. All included articles are Randomized Controlled Trials (RCTs) and evaluate the efficacy of VR systems developed after 2012 in reducing pain in pediatric patients (0 – 18 years). Six out of nine studies (66.7%) show that VR interventions are effective and safe in pediatric patients. However, these studies are heterogeneous with relatively small samples and do not take into account chronic pain.