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Methadone induction, thus, should begin at a low dose and increase gradually with daily monitoring over days or weeks. At stable daily doses, serum levels peak 2 to 4 hours after dosing, then slowly decrease, providing 24 hours without overmedication or withdrawal.
Adults—At first, 20 to 30 milligrams (mg) taken as a single dose per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 40 mg per day. Do not take more than your prescribed dose in 24 hoursEven a single opioid use can alter a healthy adult's sleep architecture. In particular, insomnia is prevalent among those undergoing methadone treatment. People who experience insomnia after methadone use self-report difficulties falling asleep or remaining asleep, along with poor sleep qualityFirst, the direct effect of methadone may cause cognitive dysfunction, as studies have shown that opiates cross the blood-brain barrier (BBB). Moreover, neurocytotoxic effect of opiates on central nervous system has been reported in animal studies.
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