Review Article
A novel mucosal RORγt+NKp46+ cell subset is a source of interleukin-22
Elena Tomasello, Ana Reynders, Eric Vivier
Published:
April 29, 2009
DOI:
10.3410/B1-28
License:
© 2009 Biology Reports Ltd2009This is an open-access article distributed under the terms of the
Creative Commons Attribution-Non Commercial License, which permits unrestricted use,
distribution, and reproduction in any medium, provided the original
work is properly cited. You may not use this work for commercial purposes
Abstract
Lymphoid tissue-inducer cells are hematopoietic cells essential for the organogenesis of several lymphoid structures during both fetal and adult life, whereas natural killer cells are key effector lymphocytes of the innate immune system. A series of recent reports has identified RORγt+NKp46+ interleukin-22-producing cells in gut and tonsils that share features with both lymphoid tissue-inducer cells and natural killer cells and that may be involved in mucosal immunity and homeostasis.