Cureus | Tumor Vasculature Targeted Photodynamic Therapy for Enhanced Delivery of Nanoparticles
SIQ
-
Rate article
What's this?
Research Article

Tumor Vasculature Targeted Photodynamic Therapy for Enhanced Delivery of Nanoparticles

Zipeng Zhen, Wei Tang, Yen-Jun Chuang, Trever Todd, Weizhong Zhang, Xin Lin, Gang Niu, Gang Liu, Lianchun Wang, Zhengwei Pan, Xiaoyuan Chen, Jin Xie

Published: May 07, 2015

DOI: 10.1021/nn501134q

License: Copyright © 2014 American Chemical Society2014American Chemical SocietyTerms of Use

Abstract

Delivery of nanoparticle drugs to tumors relies heavily on the enhanced permeability and retention (EPR) effect. While many consider the effect to be equally effective on all tumors, it varies drastically among the tumors’ origins, stages, and organs, owing much to differences in vessel leakiness. Suboptimal EPR effect represents a major problem in the translation of nanomedicine to the clinic. In the present study, we introduce a photodynamic therapy (PDT)-based EPR enhancement technology. The method uses RGD-modified ferritin (RFRT) as “smart” carriers that site-specifically deliver 1O2 to the tumor endothelium. The photodynamic stimulus can cause permeabilized tumor vessels that facilitate extravasation of nanoparticles at the sites. The method has proven to be safe, selective, and effective. Increased tumor uptake was observed with a wide range of nanoparticles by as much as 20.08-fold. It is expected that the methodology can find wide applications in the area of nanomedicine.


View Full Article  
Share

What's SIQ™?

Scholarly Impact Quotient™ (SIQ™) is our unique post-publication peer review rating process. SIQ™ assesses article importance and quality by embracing the collective intelligence of the Cureus community-at-large. All registered users are invited to contribute to the SIQ™ of any published article. (Authors cannot rate their own articles.)

High ratings should be reserved for work that is truly groundbreaking in its respective field. Anything above 5 should be considered above average. While all registered Cureus users can rate any published article, the opinion of domain experts is weighted appreciably more than that of non-specialists. An article’s SIQ™ will appear alongside the article after being rated twice and is recalculated with each additional rating.

Visit our SIQ™ page to find out more.

Close

Scholarly Impact Quotient™ (SIQ™)

Scholarly Impact Quotient™ (SIQ™) is our unique post-publication peer review rating process. SIQ™ assesses article importance and quality by embracing the collective intelligence of the Cureus community-at-large. All registered users are invited to contribute to the SIQ™ of any published article. (Authors cannot rate their own articles.)

Already have an account? Sign in.

Cancel Join Now

Share this article with your colleagues. Each email address must be separated by a comma.

Later

Download Cureus Media Kit