Cureus | LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS
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Research Article

LYMPHOCYTE ACTIVATION IN SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND CYTOMEGALOVIRUS INFECTIONS

G. B. Thurman, A. Ahmed, D. M. Strong, R. C. Knudsen, W. R. Grace, K. W. Sell

Published: October 01, 1973

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License: Copyright © 1973 by The Rockefeller University Press

Abstract

Efforts to stimulate lymphocytes from measles seropositive and two patients with subacute sclerosing panencephalitis (SSPE) with either commercially available measles virus or virus isolated from a known case of SSPE failed to show any significant data using a microculture assay. Similar results were obtained using lymphocytes from two patients with active cytomegalovirus (CMV) infections and CMV seropositive individuals using CMV suspensions. On the other hand, lymphocytes from the patients with subacute sclerosing panencephalitis exhibited in vitro blastogenesis in culture with SSPE virus-infected HeLa cells. Similarly, lymphocytes from the CMV-infected patients demonstrated blastogenesis when cocultivated with CMV-infected WI-38 cells. This affords a new method for determining the cell-mediated immune capacity of patients with "slow" virus diseases.


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Scholarly Impact Quotient™ (SIQ™) is our unique post-publication peer review rating process. SIQ™ assesses article importance and quality by embracing the collective intelligence of the Cureus community-at-large. All registered users are invited to contribute to the SIQ™ of any published article. (Authors cannot rate their own articles.)

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