Review Article
Changing the burden of COPD mortality
David M Mannino, Victor A Kiri
Published:
September 01, 2006
DOI:
License:
© 2006 Dove Medical Press Limited. All rights reserved
Abstract
COPD is a major cause of mortality and morbidity worldwide with an estimated 2.75 million deaths in 2000 (fourth leading cause of death). In addition to the considerable morbidity and mortality associated with COPD, this disease incurs significant healthcare and societal costs. Current COPD guidelines acknowledge that the following can improve COPD mortality: smoking cessation; long-term oxygen therapy; and lung volume reduction surgery in small subsets of COPD patients. To date, no randomized controlled trials have demonstrated an effect of pharmacological treatment on mortality, although several observational studies suggest that both long-acting bronchodilators and inhaled corticosteroids may provide a survival benefit. The possibility that these treatments reduce mortality is being investigated in ongoing large-scale clinical trials.