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Case report
peer-reviewed

Unprovoked Pulmonary Embolism in a Young Patient with Marfan Syndrome



Abstract

Marfan syndrome is a rare connective tissue disorder with a prevalence of approximately 2 to 3 per 10,000 individuals. There have been some reports of young patients with Marfan syndrome developing arteriovenous thromboembolism. These events were unprovoked and recurrent. Owing to its rarity, hypercoagulopathy and other metabolic derangement in patients with Marfan syndrome remains largely unknown. Herein, we report a case of a young man with Marfan syndrome who had myocardial infarction and pulmonary embolism. We hope that this case adds to the scant body of knowledge about this patient population.



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Case report
peer-reviewed

Unprovoked Pulmonary Embolism in a Young Patient with Marfan Syndrome


Author Information

Stella Pak Corresponding Author

Internal Medicine, Kettering Medical Center

Andrew Kilgore

Wright State University Boonshoft School of Medicine

Rosanne Thornhill

Loma Linda University School of Medicine

Kyle Rako

Wright State University Boonshoft School of Medicine

Ali Meier

Wright State University Boonshoft School of Medicine

Gavriella Pora

Wright State University Boonshoft School of Medicine

Jillian M. Costello

Liberty University College of Osteopathic Medicine

Christine Dee

Wright State University Boonshoft School of Medicine


Ethics Statement and Conflict of Interest Disclosures

Human subjects: Consent was obtained by all participants in this study. Informed consent obtained. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.


Case report
peer-reviewed

Unprovoked Pulmonary Embolism in a Young Patient with Marfan Syndrome


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Case report
peer-reviewed

Unprovoked Pulmonary Embolism in a Young Patient with Marfan Syndrome

Stella Pak">Stella Pak , Andrew Kilgore">Andrew Kilgore, Rosanne Thornhill">Rosanne Thornhill, Kyle Rako">Kyle Rako, Ali Meier">Ali Meier, Gavriella Pora">Gavriella Pora, Jillian M. Costello">Jillian M. Costello, Christine Dee">Christine Dee

  • Author Information
    Stella Pak Corresponding Author

    Internal Medicine, Kettering Medical Center

    Andrew Kilgore

    Wright State University Boonshoft School of Medicine

    Rosanne Thornhill

    Loma Linda University School of Medicine

    Kyle Rako

    Wright State University Boonshoft School of Medicine

    Ali Meier

    Wright State University Boonshoft School of Medicine

    Gavriella Pora

    Wright State University Boonshoft School of Medicine

    Jillian M. Costello

    Liberty University College of Osteopathic Medicine

    Christine Dee

    Wright State University Boonshoft School of Medicine


    Ethics Statement and Conflict of Interest Disclosures

    Human subjects: Consent was obtained by all participants in this study. Informed consent obtained. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

    Acknowledgements


    Article Information

    Published: September 05, 2017

    DOI

    10.7759/cureus.1655

    Cite this article as:

    Pak S, Kilgore A, Thornhill R, et al. (September 05, 2017) Unprovoked Pulmonary Embolism in a Young Patient with Marfan Syndrome. Cureus 9(9): e1655. doi:10.7759/cureus.1655

    Publication history

    Received by Cureus: August 10, 2017
    Peer review began: August 24, 2017
    Peer review concluded: August 31, 2017
    Published: September 05, 2017

    Copyright

    © Copyright 2017
    Pak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 3.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    License

    This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Marfan syndrome is a rare connective tissue disorder with a prevalence of approximately 2 to 3 per 10,000 individuals. There have been some reports of young patients with Marfan syndrome developing arteriovenous thromboembolism. These events were unprovoked and recurrent. Owing to its rarity, hypercoagulopathy and other metabolic derangement in patients with Marfan syndrome remains largely unknown. Herein, we report a case of a young man with Marfan syndrome who had myocardial infarction and pulmonary embolism. We hope that this case adds to the scant body of knowledge about this patient population.



Want to read more?

Create a free account to continue reading this article.

Already a member? Login.



Stella Pak

Internal Medicine, Kettering Medical Center

For correspondence:
stella.pak@ketteringhealth.org

Andrew Kilgore

Wright State University Boonshoft School of Medicine

Rosanne Thornhill

Loma Linda University School of Medicine

Kyle Rako

Wright State University Boonshoft School of Medicine

Ali Meier

Wright State University Boonshoft School of Medicine

Gavriella Pora

Wright State University Boonshoft School of Medicine

Jillian M. Costello

Liberty University College of Osteopathic Medicine

Christine Dee

Wright State University Boonshoft School of Medicine

Stella Pak

Internal Medicine, Kettering Medical Center

For correspondence:
stella.pak@ketteringhealth.org

Andrew Kilgore

Wright State University Boonshoft School of Medicine

Rosanne Thornhill

Loma Linda University School of Medicine

Kyle Rako

Wright State University Boonshoft School of Medicine

Ali Meier

Wright State University Boonshoft School of Medicine

Gavriella Pora

Wright State University Boonshoft School of Medicine

Jillian M. Costello

Liberty University College of Osteopathic Medicine

Christine Dee

Wright State University Boonshoft School of Medicine