Effectiveness of Treatment in Children With Cerebral Palsy

Objective: The objective of this study was to assess the effectiveness of conservative and surgical treatment in cerebral palsy children by evaluating the Medical Research Council (MRC) grading system, modified Ashworth scale, and Barthel Activities of Daily Life (ADL) scale. Method: This prospective case series was performed using a non-probability consecutive sampling technique at the Department of Orthopedic Surgery and Traumatology, King Edward Medical University/Mayo Hospital, Lahore from October 2011 to November 2013. Two hundred children of all ages, having cerebral palsy diagnosed on history and clinical examination were enrolled in the study. Children were treated with conservative and surgical treatment. Pre- and post-treatment, all children were classified based on movement disorder (spastic, athetoid, ataxic, and mixed), parts of the body involved (paraplegic, tetraplegic, diplegic, hemiplegic, monoplegic, double hemiplegic, and triplegic), and gross motor function (GMFCS level I-IV). Their muscle power and tone were assessed using the MRC grading system and modified Ashworth scale, respectively. Assessment of disability and daily function was done by ranking disability grading and Barthel ADL, respectively. The range of motion (ROM) of each joint was assessed clinically. Children were divided based on the treatment method as non-surgical versus surgical treatment. Results: Out of a total of 200 children, the mean age of the children was 7.86±4.17year. There were 134 (67.0%) males and 66 (33.0%) female children. Classification on basis of movement disorder, body part involved, and gross motor function at three-month intervals till twelve months was performed. From the first presentation of children till the last follow-up time period, i.e., 12th month there was no change in the movement disorder (a type of CP, body parts involved, and GMFCS). The final rating of overall treatment results shows that there were 84 (42%) patients who had a poor outcome, and only 35 (17.50%) patients had a fair treatment outcome and 81 (40.50%) patients had good treatment outcomes. Conclusion: The conservative and surgical management showed no effect on movement disorder of the child although, on the final rating scale fair to good treatment outcome was observed in all children. There was an improvement in muscle power grading on the ADL, but no significant improvement was seen on the improvement of type, parts of the body involved, gross motor function classification, modified Ashworth, and ranking disability grading of the children.


Introduction
Cerebral palsy (CP) is a group of non-progressive disorders of the brain and nervous system dysfunction. It affects the child's movement, vision, learning, and thinking processes [1]. It can occur before birth, during birth, and within the first year of childbirth [2]. It appears as a result of brain injuries and abnormalities that can present two years after birth. In some children, it occurs as a result of brain hypoxia while premature infants have a higher risk of developing CP [3,4].
The reported incidence of CP is 1.5 to 2.5 per 1000 childbirth. These incidences were higher between 1960 and 1980. Now, data have reported 0.5 per 1000 childbirths [5]. Diplegic CP has a 95% survival rate versus 75% in quadriplegic children till the age of 30 years. Survival of mild to severe mental retard rate has been reported as 65% and 90%, respectively, till the age of 38 years with an overall survival rate is 90% till the age of 20 years [6].
CP is the second most common disease after mental retardation that causes disability in child growth, but it also affects adults. There is a lack of special training amongst primary healthcare physicians and specialists for treating children with developmental abnormalities [7]. The symptoms of CP vary according to the presentation. It can be mild to severe with one side or whole of the body involvement [8]. Increasing research work to understand the hormonal, infection, and genetic factors are involved in premature births of babies given by the mother [9,10].
The goal for these children, their families, medical care, education, and society at large is for them to grow and develop to their maximum capabilities so that they may succeed as contributing members of society. We studied the conservative and surgical treatment outcome of CP children. It helped us understand the problem of the CP, treatment options, and their outcomes with the passage of time.

Materials And Methods
This prospective case series was done using a non-probability consecutive sampling technique at the Department of Orthopedic Surgery and Traumatology, King Edward Medical University/Mayo Hospital, Lahore from October 2011 to November 2013. Two hundred children of all ages, having CP diagnosed on history and clinical examination were enrolled in the study. Children with complications (bed sores), systemic illness (diabetes mellitus, ischemic heart disease, asthma, Hepatitis B, and Hepatitis C) skin disease, and malignancy were excluded from the study.
After obtaining ethical permission from the university institutional review board (IRB), informed written consent was obtained from parents of the children. We obtained demographic data of all the children. Pretreatment, all children were classified based on movement disorder (spastic, athetoid ataxic, and mixed), parts of the body involved (paraplegic, tetraplegic, diplegic, hemiplegic, monoplegic, paraplegic, double hemiplegic, and triplegic), and gross motor function (GMFCS level I-IV). Their muscle power and tone were assessed using the Medical Research Council (MRC) grading system and modified Ashworth scale, respectively. Assessment of disability and daily function was done by ranking disability grading and Barthel Activities of Daily Life (ADL), respectively. The range of motion (ROM) of each joint was assessed clinically. Children were treated with conservative and surgical treatment methods.
Children were followed up in the out-patient department at a three-month interval for twelve months. They were evaluated based on movement disorder (spastic, athetoid ataxic, and mixed), body part involved (paraplegic, tetraplegic, diplegic, hemiplegic, monoplegic, paraplegic, double hemiplegic, and triplegic), GMFCS level I-V, muscle power by MRC grading, tone by modified Ashworth score. Disability and activity of daily life were assessed using ranking disability grading and Barthel ADL chart, respectively. Active and passive ROM, gait patterns, and complications were recorded clinically.
Data obtained were coded and tabulated on the spreadsheet. SPSS version 18 (IBM Corp., Armonk, NY) was used to analyze data (continuous variable age, height, and weight) that were presented in the form of a table and histogram. Mean, mode, range, and stranded deviation were used to see the central tendency and measures of dispersion. The descriptive statistics of the categorical variable was present in the form of ratio, graphs, and tables.

Results
Children's routine investigations were done. Routine investigations include a comparison of the type of nonsurgical and surgical treatments used for children with CP which was enlisted in Table 1. The type of CP, type of body part involved, gross motor function classification, and special tests of children with CP before treatment are given in Table 2.   On follow-up, classification on basis of movement disorder, body part involved, and gross motor function at three-month intervals till twelve months was done. From the first presentation of children till the last follow-up time period, i.e., 12th month, there was no change in the movement disorder ( Table 3).   The ROM was assessed for 12 months follow-up time period. In the 3rd month, there were 92 children whose ROM was increased, at 6th month, there were 177 children whose ROM was increased, at 9th month, there were 154 children whose ROM was increased, and in the 12th month, there was a total of 181 children whose ROM was increased. It shows that after treatment ROM improves with the passage of the follow-up time period.
Assessment of muscle power grading, muscle tone, disability, and activity of daily life was done using the MRC scale, modified Ashworth scale, ranking disability grading, and Barthel ADL, respectively. Scoring was done on the first presentation until the last follow-up. The effects of treatment have been given in Table 4.  The gait of children at different time intervals during the follow-up time period was observed. Limping gait was improved from 41 children at 3rd months to 29 children at 12th months of follow-up. Dancing gait was present in 13 children and ataxic gait in 7 children until the last follow-up time period. There were 15 children in which crouch gait was observed in the 3rd month and at the 12th-month crouch gait was observed in 9 children. At 3rd and 6th month, 87 children were bedridden, at 9th month 80 children and at 12th month 73 children were bedridden. Similarly, 37 children do crawl at 3rd month and till the 12th months, 28 Children do crawl.
In the 3rd month, 13 children had complications, at the 6th and 9th month, 8 children had complications, and at the 12th month, only 7 Children had complications. The final rating of overall treatment results shows that there were 84 (42%) children who had poor outcomes, only 35 (17.50%) Children had a fair treatment outcome, and 81 (40.50%) Children had good treatment outcomes.

Discussion
In every 1000 live births, the CP rate as a whole was between 2 and 3. But may increase up to 40-100 per 1000 live births in premature and low birth weight newborns [11]. Diplegia, hemiplegia, and quadriplegia (involvement of all four limbs) were involved to explain the clinical patterns of CP. The term double hemiplegia suggested bilateral involvement described by greater involvement of the arms than the legs. Asymmetrical involvement or a clearly dominant side was suggested by some practitioners to explain this term. Spasticity, rigidity, hypotonia, dystonia (e.g., athetosis), or a mixture of these disorders were some movement disorders and they can coexist with clinical patterns [12].
Lack of specific diagnosis procedures for diplegia, quadriplegia, and hemiplegia was very difficult to access for clinical processing. The distribution of clinical patterns was identified in a study in France done by Bleck and the percentage that came out was quadriplegia was 40%, diplegia was 17%, and hemiplegia was present in 21% of children [13]. The Central West Health Planning Information Network (Ontario, Canada) reported that the percentage of non-specific classified children was 45·7%. The Canchild Centre for Childhood Disability in Ontario reported the gross motor function classification system; they took 408 children for this purpose and divided into five different levels: level I, 112 (27·5%); level II, 47 (11·5%); level III, 81 (19·9%); level IV, 82 (20·1%); and level V, 86 (21·1%). Level I indicates few limitations and level V severe impairments, respectively [14].
Clinical findings were used primarily for the determination of CP as the spasticity management technique in children. Spasticity, muscle stiffness, muscle contracture, dynamic and static joint deformity, torsional deformities, and abnormal motor control are some of the parameters which were mandatory for the treatment of musculoskeletal abnormalities. The use of a continuum of modalities throughout childhood was one of the basic management for spasticity; a combination of modalities was seen to be used in the majority of children. It was investigated that small doses of drugs given orally for reduction of spasticity were effective comparatively. It was concluded that the botulinum toxin injection was used intramuscularly for the management of focal spasticity. The effect of the injection could be increased if it was associated with physiotherapy and orthotics as well [16][17][18].
Occupational therapy, physiotherapy, and speech therapy, device-assisted modalities (e.g., electrical stimulation), orthotics, casting, or any combination of these methods are the non-pharmacological approaches used for treatment. Joint ROM, facilitate or strengthen weak muscles, inhibit or weaken spastic agonist muscles, provide support, improve muscle strength, and improve or normalize motor development.
The surgical methods, which were used, for the treatment of children, included tenotomy, tendon lengthening, tendon transfer, muscle lengthening, neurectomy, capsulotomies, osteotomies, and arthrodesis. Significant improvement was seen as a result of these treatment modalities. Muscle power, muscle tone, ROM, and gait analysis were improved.
Physiotherapy, occupational, and/or speech were given to most of the children suffering from CP. There is little evidence-based information supporting or refuting their usage in the management of CP [19][20][21]. Maximum benefits were attained from physiotherapy and occupational therapy that were important factors for successful medical and surgical intervention [22]. Muscle-strengthening has been associated with improved function in children with CP [23]. Strength training has been advocated to promote fitness and increase children's participation in various recreational and occupational activities. Physiotherapy and occupational therapy interventions include a wide range of techniques and schools including classic neurodevelopmental therapy techniques [24,25] and constraint-induced movement [26].
Constraint-induced therapy treatment models developed for rehabilitation of the arm in adults with stroke are now under investigation for use in children with CP. Preliminary case studies or trials with small numbers of children suggest that constraint-induced therapy results in improvements in hand function. However, further research is needed to define the long-term effects of this intervention in children with CP [27].
Our data have not shown the good effect of treatment on movement disorder of the CP children although there was an improvement in muscle power and improvement on the activity of daily life of CP in our study. Our study has a short follow-up to observe the treatment outcome of CP. Large follow can better predict the effect of conservative and surgical treatment outcomes in CP children.

Conclusions
Both treatments (conservative and surgical) have a good effect on the final rating scale of treatment on CP child ranging from fair to good outcomes. There was an improvement in muscle power grading on the ADL, but no significant improvement was seen on the improvement of type, parts of the body involved, gross motor function classification, modified Ashworth, and ranking disability grading of the children.

Additional Information Disclosures
Human subjects: Consent was obtained or waived by all participants in this study. ADVANCED STUDIES & RESEARCH BOARD issued approval 7099. The Research Board is pleased to approve your study which is doable and will help in making treatment strategies. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.