Complications and Mortality in Hospitalised Patients With Decompensated Cirrhosis of Liver in a Tertiary Care Centre in Nepal

Background Patients with decompensated cirrhosis present with various complications and are associated with increased inpatients mortality. This study aimed to evaluate the complications and mortality in hospitalised patients with decompensated cirrhosis of liver. Methods This descriptive, cross-sectional, hospital-based study included 754 decompensated cirrhotic patients. The primary endpoints were mortality and hospital stay. The data analysis was done using Statistical Product and Service Solutions (SPSS) version 20 (IBM Corp., Armonk, NY). The chi-square test was used to compare the differences between different predictors of mortality with p<0.05 considered significant. Results A total of 754 patients (mean age 54±11.51 years; male/female ratio of 3.6:1) were studied. Ascites was the most common complication (99.2%) followed by upper gastrointestinal (UGI) bleed (42.3%), hepatic encephalopathy (32.5%), rebleeding (33.2%), spontaneous bacterial peritonitis (26%), and hepatorenal syndrome (19.1%). Inpatient mortality was 19.8%. The most common causes of mortality were rebleeding (21.5%) followed by hepatic encephalopathy (HE) (18.7%), hepatorenal syndrome (HRS) (14.7%), and spontaneous bacterial peritonitis (SBP) (12.1%). The presence of Grades IV HE, the presentation with shock, Child Turcotte Pugh (CTP) C, rebleeding, variceal bleed, HRS, hyponatremia (<130 mEq/L), the requirement of ≥3 units of blood and blood products, co-existence of hepatocellular carcinoma (HCC), and multiple comorbidities and complications in a single patient were strong predictors of mortality (p≤0.05). Conclusions Ascites followed by UGI bleed, hepatic encephalopathy, rebleeding, spontaneous bacterial peritonitis, and hepatorenal syndrome were common complications among the admitted decompensated cirrhotic patients. Inpatient mortality was high. The most common cause of mortality was rebleeding followed by hepatic encephalopathy, HRS, and SBP.


Introduction
Liver cirrhosis is a progressive chronic liver disease. Histologically, it is characterized by diffuse, fibrosing and nodular condition that disrupts the normal architecture of the liver [1]. The main aetiological causes are excessive alcohol consumption, chronic viral hepatitis B and C, obesity, and nonalcoholic fatty liver disease. The clinical presentation of cirrhosis varies with the aetiology. Clinical features of cirrhosis are secondary to portal hypertension and/or hepatocellular injury. Many times, patients may present with severe liver injury without any obvious clinical signs [2]. Cirrhosis is classified into two stages: compensated and decompensated. Decompensated cirrhosis has either jaundice or varied complications like splenomegaly, ascites, spontaneous bacterial peritonitis, hepatic encephalopathy, development of esophagogastric varices, and variceal bleed [1]. Liver cirrhosis is an important health problem worldwide and is associated with increased morbidity and mortality. About 80% of patients with newly diagnosed hepatocellular carcinoma (HCC) have preexisting cirrhosis [3].
Liver cirrhosis is a common disease in Nepal, especially with easy accessibility and very common use of alcohol. National data on decompensated cirrhosis and complications in hospitalized patients are scarce. This research was undertaken to study the various complications and assessments of mortality among hospitalised patients with decompensated liver cirrhosis admitted at Manipal College of Medical Sciences and Teaching Hospital, a tertiary care hospital in Gandaki Province, Nepal.

Materials And Methods
This descriptive, cross-sectional, hospital-based study was carried out in the unit of Medical Gastroenterology under the Medicine department at Manipal College of Medical Sciences and Teaching Hospital, Nepal from January 2018 to June 2020 over a period of 30 months. The study was approved by the Institutional Review (MEMG/IRC/374/GA). Informed consent was obtained from patients or patient relatives.
All cases with jaundice or ascites or any other clinical features suggestive of decompensated cirrhosis of liver admitted in the ICU and/or ward admitted under unit of Medical Gastroenterology at Manipal Teaching Hospital were included in the study. Child Turcotte Pugh (CTP A, B or C) scoring system was used to assess the severity and prognosis whereas West Haven Classification (Grade I to IV) was used for grading of hepatic encephalopathy. Stable cirrhotic patients presenting to outpatient department (OPD), patients with compensated cirrhosis, acute fulminant hepatitis or those with non-cirrhotic portal hypertension, those with incomplete records, and those who fail to give consent were excluded from the study.
Data regarding demographic variables, varied presentation, and complications at admission were documented. Blood investigations like complete blood count, platelet count, blood grouping, electrolytes, liver function test, prothrombin time/international normalized ratio (PT/INR), coagulation profile, tumour marker (alpha fetoprotein ) for HCC and viral serologies were collected. Ultrasonography and computed tomography (CT) scan of the abdomen were done for assessment of liver echogenecity and to rule out hepatocellular carcinoma, collateral vessels, and evidence of other features of portal hypertension and other complications. Upper GI endoscopy was done for screening of varices and evaluation of upper GI bleed. Therapeutic endoscopic variceal band ligations were performed with bleeding and/or large varices. Clinical outcomes of these decompensated liver cirrhotic patients during hospitalization including mortality were studied.

Data analysis and statistical methods
Data were collected on a structured proforma. All categorical data were expressed in percent and absolute number. All numerical continuous data were expressed in mean±SD. Chi-squared test was used to test for significant difference of proportions (categorical data). All tests were analyzed with a 95% confidence interval and a p-value of <0.05 was considered statistically significant. The data analysis was done using Statistical Product and Service Solutions (SPSS) version 20 (IBM Corp., Armonk, NY).

Results
A total of 796 patients were screened for study eligibility. However, 25 patients were taken away to home or elsewhere by relatives against medical advice despite initial management and few days of admission, and 17 were excluded because of inadequate data. Finally a total of 754 patients comprising 590 (78.2%) male and 164 (21.8%) female cirrhotic subjects were eligible for the study (M:F=3.6:1).
The mean age of subjects was 54±11.51 years with a range of 24-85 years of age. Patients were further classified as per sex and age groups as in Table 1 with maximum cases in 50-69 years of age group.  The mean hospital stay of the patients was 6.3 days. One hundred and forty-nine (19.8%) had inpatient mortality within 14 days. The most common causes of mortality were rebleeding (21.5%) followed by hepatic encephalopathy (18.7%), HRS (14.7%), SBP (12.1%), and sepsis (10.7%). Deaths due to pneumonia and coronary artery diseases were also common (  The presence of HE of Grades IV, the presentation with shock, CTP C, rebleeding, variceal bleed, HRS, hyponatremia (<130 mEq/L), the requirement of ≥3 units of blood and blood products, co-existence of HCC, multiple comorbidities, and complications in a single patient were significant predictors of increased mortality (p≤0.05; Table 3).   [4,6].
Inpatient mortality was seen in 19.8% in the current study. It was 19.1% and almost similar in the study by Pathak et al. in a previous Nepalese study [11]. The most common causes of