Severity of Coronary Artery Disease in Prediabetic Patients Undergoing Elective Coronary Angiography

Introduction Our objective was to determine the severity frequency of coronary artery disease (CAD) in prediabetes patients undergoing coronary angiography (CAG) in a catheterization laboratory. Materials and methods This descriptive comparative study was conducted on patients who were planned for elective CAG in the hospital from January 2019 to November 2019. The study includes patients age ≥40 years undergoing elective CAG with or without percutaneous coronary intervention/percutaneous transluminal coronary angioplasty. There were 458 patients (381 men and 77 women) in this study that were categorized into three groups on the basis on their glycated hemoglobin (HbA1c) levels: group I (n = 143) as non-diabetes, group II (n = 110) as prediabetes, and group III (n = 205) as diabetes. The severity of CAD was determined using the Gensini score. Results A total of 458 patients were included. Of these, 44.97% had hypertension; n = 36 (25.17%), n = 48 (43.63%), and n = 122 (59.51%) in group I, group II and group III, respectively (P = .0001). A total of 214 (46.72%) had a smoking history. There was a strong family history of CAD in group II (n = 29, 26.36%) and group III (n = 43, 20.98%). Group II and group III patients had a higher extension of CAD than group I (P = .01). Group II (n = 27, 41.54) and group III (n = 65, 50.39%) had a higher frequency of deployment of two stents compared to group I. Conclusion Coronary artery atherosclerosis disease increases parallel to the HbA1c severity and smoking. The present study emphasizes prediabetes as an independent risk factor for CAD.


Introduction
1 1 Diabetes is an unusual level of blood glucose that damages the body's ability to process blood sugar. Prediabetes is an intermediate condition between diabetes and non-diabetes glucose values. Prediabetes patients are more prone to type 2 diabetes (T2D) within three to five years [1]. In the United States, one in three individuals has prediabetes (an estimated 33.9%) [2]. There is a prevalence rate of 7.9% around the world and 10.91% in Pakistan [3,4]. Individuals with prediabetes may have a 20% higher chance of cardiovascular disease and atherosclerosis risk compared to non-diabetic individuals [5]. Prediabetes causes diffuse lesions and creates tiny blood vessels that make unstable plaques in coronary arteries [6,7]. Early diagnosis and control of prediabetes are necessary to avoid T2D and vascular complications.
In 2008, the American Diabetes Association and the International Diabetes Federation formed a committee to review and diagnose T2D via a convenient and easy method. The committee recommended using glycated hemoglobin (HbA1c) level to provide an accurate diagnosis of T2D. HbA1c measurement provides a better diagnosis than fasting blood glucose and oral glucose tolerance test [8]. The present study was conducted to observe and compare the severity of coronary artery disease (CAD) in prediabetes patients with those of healthy individuals and T2D patients.

Materials And Methods
This was a descriptive comparative study, conducted at the Chaudhry Pervaiz Elahi Institute of Cardiology of Multan, Pakistan. Patients with chest pain and undergoing elective coronary angiography (CAG) in a cardiac catheterization lab (CCL) from January 2019 to November 2019 were included. The study included patients age ≥40 years undergoing elective CAG with or without percutaneous coronary intervention (PCI)/percutaneous transluminal coronary angioplasty (PTCA). No specific exclusion criteria were selected. The study was approved by the institutional ethical committee and research body. Written and informed consent was obtained from all patients.
The atherosclerotic burden on CAD vessels was assessed by the Gensini score ( Table 1). The number of stents used was recorded group-wise. Other blood parameters such as plasma glucose, HbA1c, creatinine kinase, electrolytes, and blood count were analyzed in the central laboratory of the hospital.  CAG was performed using the Judkins method with a puncture of either radial artery or femoral artery. CAD extension was defined as shown in Table 2. CAG results were assessed by two individual cardiologists. An in-house Philips software system calculated the percentage of coronary stenosis in CCL.

Results
Patient demographics and baseline clinical values are presented in Table 2 Interventional data are shown in Table 3. Group II (n = 27, 41.54) and group III (n = 65, 50.39%) had a higher frequency of deployment of two stents compared to group I (n = 25, 33.33%, P = .17). Group II had more coronary atherosclerotic complex anatomy with a higher Gensini score (28.0 ± 6.0, P < .001) than group I (20.0 ± 6.0) and group III (22.0 ± 8.0).

Discussion
We assessed the incidence of atherosclerosis CAD and its burden in prediabetes and its impact on coronary vessels and CAG outcomes. In our study, 110 (24.01%) patients had prediabetes; the prevalence of men was high in all groups, while in other studies, women were predominant in the diabetes group [10,11]. The frequency of prediabetes with smoking and CAG + PCI/PTCA is higher in the prediabetes group, similar to the other studies conducted by Muhammed et al. [10]. Our study results found no statistical significance in smoking among the groups. However, HTN correlated with smoking; as the prevalence of HTN increased, the rate of smoking frequency increased. Choi et al. and Zhang et al. also reported results consistent with ours; people with prediabetes had a higher prevalence of HTN than those without diabetes undergoing elective CAG [12,13]. The reason for this explained by Kamalesh et al. in their study [14]. Patients with elevated HbA1c levels had a strong family history of CAD (P = .005) in both the prediabetes and diabetes groups compared to the non-diabetes group. Similarly, Acar et al. found that the prediabetes and diabetes groups had a higher prevalence of dyslipidemia based on a standard screen test [15]. Ashraf  . The Gensini score in our study was 28.0 ± 6.0 in prediabetic patients, higher than those of euglycemic and diabetic patients (F = 43.52, P < .001).
Prediabetic patients have more severe CAD when compared to euglycemic patients. So, recommending a healthy lifestyle, timely medical treatment, and regular physical activity may prevent prediabetes in those prone to diabetes and decrease their risk of cardiovascular disease.
A limitation of this research is that this was a single-center study with a limited sample size. Similar studies should be carried out in a larger population center with more variables to confirm the severity of CAD outcomes.