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Bruce Maciver
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Bruce Maciver

Ph.D. | M.Sc. | Professor | Anesthesiology

Anesthesia, Stanford University School of Medicine
Professional Societies
  • Society for Neuroscience
  • ASA
  • AUA Anesthesia
High Dose Gamma Radiation Selectively Reduces GABAA-slow Inhibition
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High Dose Gamma Radiation Selectively Reduces GABAA-slow Inhibition

Original Article
Commented on: March 04, 2017

An interesting point Robert, and thanks for commenting, but the decrease in GABA-mediated inhibition we observed would likely be too small to result in the kind of neuronal hyperexcitability that would lead to seizures. To get seizure activity by disinhibition or blocking GABA transmission, you need the level of block produced by a strong antagonist like picrotoxin, or the receptor blocker we used, gabazine (our Figure 3), where the appearance of multipled spike discharges occurs. This was nicely demonstrated by David Prince many years ago, using a variety of ways to block GABA inhibition and produce epileptic seizures. The disinhibition produced by radiation, on the other hand, is comparable to that produced by therapeutic doses of antidepressants (see ref in our discussion). It should also be noted that seizures are not a common side effect of gamma radiation when used in humans.


The Study of EEG Dynamics During Anesthesia with Cross-Recurrence Rate

Original Article
Commented on: October 19, 2016

Looks like a nice improvement compared to commercially available monitors for depth of anesthesia.